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GLP-1 therapy is generally not recommended during breastfeeding due to theoretical concerns about infant exposure and caloric restriction during lactation

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Also, patients should be warned about the danger of taking folic acid in place of vitamin B 12, because the former may prevent anemia but allow progression of subacute combined degeneration

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A 2023 crossover trial in fatigued office workers found 500 mcg daily for 8 weeks slashed fatigue scores by 25%, linked to optimized homocysteine metabolism