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What the 2025 Tirzepatide/TRT Study Showed A 2025 clinical pilot study (La Vignera et al., Reproductive Biology and Endocrinology) compared overweight men treated with tirzepatide to those receiving testosterone therapy (TRT)

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Sleep deprivation impairs leptin signaling and increases hunger hormones, so prioritizing 79 hours per night can unlock additional progress

5-8 Clinical trials confirmed blood sugar benefits and showed that these medications also reduce risk of cardiovascular events in diabetics, including heart attack and stroke, by as much as 26%