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Tirzepatide vs Semaglutide Side Effects, Risks, and Safety Comparison Share Jean-Phillip Okhovat, MD, MPH Harvard & UCLA Trained Physician April 14, 2026 15 min read Tirzepatide vs Semaglutide Side Effects, Risks, and Safety Comparison During the last decade, the discussion on obesity has shifted quickly

Most patients begin to notice gradual weight loss within the first month of treatment, although it may take up to 3 months for the full effects to become evident

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Semaglutide promotes weight loss by empowering you to eat fewer calories on a daily basis