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Rizzo et al., 2015, 2016), drug administration has been challenging

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The procedure of choice is called a lateral internal sphincterotomy, which relaxes the internal anal sphincter by cutting this muscle

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[5] In aged rats with memory trouble, Dihexa pushed maze performance back toward young-control levels, and its effect per dose is genuinely large for a research peptide active at concentrations far below its parent compound

10.1016/j.phrs.2019.01.019 Pharmacol Res