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Being anti-oxidants, vitamins C and E may theoretically play a role in neuroprotection by decreasing glutamate-mediated excitotoxicity and interfering with SN oligomerization (Kocot et al

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Thus, the scarce human studies performed so far, regardless of all of the limitations in some of them (i.e., they lacked a large sample size, ethnic variation, and a sham control group), encompassed a wide range of investigations (i.e., ulcerative colitis [65], knee pain [263], and interstitial cystitis [264])

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Diagnosis usually entails measuring serum levels of vitamin B12 or identifying elevated levels of methylmalonic acid and homocysteine