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However, a clinical study demonstrated that the Treg level was negatively correlated with the severity of RE and that Treg function was impaired in RE patients, demonstrating the complex mechanism of Tregs in RE development 52

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This review confirms that pharmaceutical residuesintroduced through manufacturing, consumption, and improper disposalpersist in aquatic and terrestrial ecosystems, with documented effects including endocrine disruption, neurotoxicity, and the propagation of antimicrobial resistance