Campbell, D.J., et al
Moreover, biodegradable MPs increased potentially harmful Megamonas and Prevotella with SCFA production impairment, authors hypothesizing that biodegradable plastics may cause greater harm than conventional plastics because their degradation creates oligomerssmaller breakdown products that can more easily penetrate biological barriers and further exhibit detrimental effects on gut microbiota (Peng et al., 2024)
Sterile water works for reconstitution but dramatically shortens shelf life
In some embodiments, the otic formulation or composition contains at least one viscosity modulating agent that provides the otic formulation or composition with a viscosity of at least about 10 cP, about 20 cP, about 30 cP, about 40 cP, about 50 cP, about 60 cP, about 70 cP, about 80 cP, about 90 cP, about 100 cP, about 200 cP, about 300 cP, about 400 cP, about 500 cP, about 600 cP, about 700 cP, about 800 cP, about 900 cP, about 1000 cP, about 2,000 cP, about 3,000 cP, about 4,000 cP, about 5,000 cP, about 6,000 cP, about 7,000 cP, about 8,000 cP, about 9,000 cP, about 10,000 cP, about 15,000 cP, or about 20,000 cP
It has been shown to reduce levels of pro-inflammatory markers such as IL-6 and TNF-, which are implicated in diabetic complications and cardiovascular disease
The Phase 2 data proves it: fast escalation to 8 mg doubled GI adverse event rates compared to gradual titration