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Intramuscular (IM) injections bypass the gastrointestinal tract entirely, making them particularly effective when oral absorption is unreliable or when a confirmed deficiency requires prompt correction

SIM1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus

Individuals with severe deficiency might require a series of injections before experiencing significant changes in their mood or energy levels

Shulman GI

They replace deficient B12 when absorption or intake is inadequate

Regular follow-up appointments and adherence to monitoring protocols are essential to ensure the safe and effective use of these medications