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As the duodenum fills, stretch receptors are activated that inhibit the vagus nerve, which results in reduced gut tone and motility, temporarily reducing gastric emptying

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*Contraindications to Semaglutide include a personal or family history of medullary thyroid cancer, allergy to Semaglutide, Type 1 Diabetes or history of Diabetic Ketoacidosis, personal or family history of Multiple Endocrine Neoplasia, personal history of Pancreatitis, renal impairment or kidney disease, gallbladder disease, or concurrent use of anti-diabetic medications or insulin