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* **Addressing Weight-Related Comorbidities:** Tirzepatide has shown benefits for conditions often linked to obesity: * **Obstructive Sleep Apnea (OSA):** Zepbound is FDA-approved to treat moderate-to-severe OSA in adults with obesity, demonstrating significant reductions in sleep apnea events alongside weight loss

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When GLP-1R agonists penetrate the blood-brain barrier and reach this region, they can trigger nausea signals

The nerve growth factor 35 years later