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Both hormones interact with specific receptorsGLP-1R and GIPRbelonging to the G-protein coupled receptor family, which triggers metabolic pathways crucial for glucose regulation and energy balance

A balance should be maintained to avoid pitfalls associated with over-supplementation, keeping magnesium as part of a broader, individualized nutritional approach

(6) Pregnancy or lactation

Risk-of-bias visualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments

A.TsikasD.MehlsC.GutzkiF.-M.BgerR

NICE recommend tirzepatide and semaglutide for patients with at least one weight-related comorbidity and a BMI 35 kg/m 2 (or BMI 30 kg/m 2 and who meet the criteria for referral to specialist weight management services, for semaglutide only) and liraglutide for patients with a BMI 35 kg/m 2 , non-diabetic hyperglycaemia, and a high risk of cardiovascular disease