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(3) Immunohistochemistry staining: for detection of Phospho-Tau-T217 aggregation in the hippocampus (anti-Phospho-Tau-T217 antibody, ABclonal company, China, dilution 1/100, catalog no.: AP1233)

For the primary endpoint of HbA1c reduction, the mean changes from baseline were -1.87%, -1.89%, and -2.07% for the 5 mg, 10 mg, and 15 mg doses, respectively, compared to a +0.04% change for placebo

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The recommendation is to use additional contraceptive methods (or switch to non-oral contraception) during GLP-1 therapy, especially during dose changes