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A multicenter prospective cohort study that followed 319 patients with SCAs (15 years) found no difference in the rate of disease progression over two years between those taking supplemental coenzyme Q 10 (median dose, 600 mg/day) and nonusers (81)
188 This was further corroborated in a systematic review of six clinical trials conducted in 2017
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Because of this, clinical settings often relied exclusively on intravenous (IV) glutathione or precursor amino acids to raise intracellular levels
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