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Indeed, pancreatic nesidioblastosis (a hyperplasia of islet cells that is potentially driven by elevated secretion of GLP1) has been implicated in the pathogenesis of refractory hypoglycaemia

Many articles have now concluded that GLP-1 agonists are associated with early worsening of existing DR (EWDR)

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It can range from mild queasiness to "I need to sit down for 20 minutes." Strategies that help: starting at 1.25 mg, staying hydrated, having a small amount of food in your stomach (not a full meal, not completely empty)

The goal is clarity