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Biochemistry 1984

Human relevance would require sufficient published, peer-reviewed controlled human studies, safety evaluation, pharmacokinetic understanding, toxicology data, and regulatory reviewevidence that has not yet been established at the level required for clinical or consumer-use conclusions

Schizophrenia synaptic pathology and antipsychotic treatment in the framework of oxidative and mitochondrial dysfunction: translational highlights for the clinics and treatment

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In addition, pharmacokinetic properties such as drug-likeness, gastrointestinal absorption, and blood brain-barrier (BBB) permeability are important to consider when evaluating its ADME profile (Daina et al., 2017)

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