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Chemotherapy rescues hypoxic tumor cells and induces their reoxygenation and repopulation - an effect that is inhibited by the hypoxia-activated prodrug TH-302

For a medication class that has demonstrated 15-22% average body weight loss in clinical trials, the cost barrier of brand-name products has been a public health issue

The 21-28 day recommendation accounts for this additional degradation pathway

However, patients should verify individual provider qualifications, as telehealth platforms vary in the depth of subspecialty training or obesity-medicine certification among their networks

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