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The deleterious effects of estrogen deficiency on the skin are well-documented (Stevenson and Thornton, 2007

Ling Yin, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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More importantly, these findings corresponded clinically with improved cardiac function in vivo, as assessed by echocardiography