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In addition, Matesanz-Snchez et al.s study showed that a decrease in EXT2 levels can cause dysregulation of lipid metabolism and antioxidant capacity by altering SAM and transsulfuration pathway enzymes levels, triggering lipid peroxidation and ultimately leading to ferroptosis in GBM cells [12]

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Similarly, the phase 3 trial EXPEDITION-3 demonstrated that 400 mg solanezumab administered every 4 weeks did not have significant effects on cognitive decline in patients with mild AD [52]