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Among three selected compounds, Withasomidienone and 2,3-Didehydrosomnifericin interacted in similar mode where aromatic withanolide backbone interacted with aromatic region while their opposite polar part interacted with polar region of the active site

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For clinicians, we hope these findings may prompt a more thoughtful, individualized approach when considering these therapies in higher-risk patients who have both obesity and autoimmune disease.

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GSH is a universal antioxidant molecule, because it can quench nearly every kind of ROS, including O, H 2 O 2 , OH, and peroxidized lipids (51, 52)

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In a controlled double-blind study, single and multiple DSIP injections normalized disturbed sleep patterns, and participants showed better performance and increased alertness during waking hours, along with improved stress tolerance

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