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Partial Agonism and Signaling Bias Orforglipron functions as a partial agonist at the GLP-1 receptor, meaning it produces submaximal activation compared to full agonists such as native GLP-1 or semaglutide

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Int J Antimicrob Agents 39, 346351, doi: 10.1016/j.ijantimicag.2011.12.003 (2012)

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