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At 2 weeks of age and 7 to 8 days after the induction of gene KO by Tam, the TamCar IGF-IR / mice show significant growth retardation with a body weight that was 70% of their control littermates, and demonstrate severely disorganized growth plates again, due to reduced cell proliferation and delayed differentiation, indicating comparable IGF-IR actions in growth plate development during embryonic and postnatal development (32)

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Preclinical work has reported a distinct selectivity profile, with growth hormone stimulation observed at concentrations that did not trigger ACTH or cortisol secretion, making it a useful tool for isolating growth hormone-specific signalling without activation of the hypothalamic-pituitary-adrenal axis

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Stepwise multiple regression identified significant predictors, and standardized regression coefficients assessed their importance