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Week 2 to 4: Improved hydration and skin texture

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the underlying cellular environment, oxidative stress, mitochondrial function, and detoxification capacity, shapes how you age and how well you respond to every other treatment

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observed nearly similar results of our ultrastructural observations in MTX-treated rats and reported that rats administered a low dose of MTX (1 mg/kg once weekly) had severe renal tissue damage and disturbance in renal functions, which was linked to elevated oxidative stress as well as MTXs pro-inflammatory and pro-apoptotic effects