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However, clinical studies have shown that treatment with leptin or its analogues does not significantly affect body weight, fat mass, glucose and insulin homeostasis, lipid profile, or food intake in individuals with obesity compared to placebo [76,77,78,79]

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492 On the other hand, mutant p53 can upregulate the expression of multidrug resistance proteins (such as MDR1), leading to increased drug efflux and increased chemotherapy resistance

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