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Two patients (7%) had hyperlipodystrophy at the injection site

Acknowledgements The authors thank current and former members of their laboratories for contributions and discussions that informed the work summarized in this Review

SGLT1, sodium-glucose cotransport protein 1

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Moreover, acetyl-l-carnitine is an epigenetic regulator of genes involved in analgesia such as the metabotropic glutamate 2 receptor in the presynaptic neurons and of neurotrophic factors including nerve growth factor