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doi: 10.1089/jmf.2014.0064 107 ShinSSSongJHHwangBNohDHParkSLKimWTet al

Both preclinical and clinical studies show that circadian disruption aggravates BBB injury, characterized by reduced expression of tight junction proteins (ZO-1, occludin, claudin-5), heightened neuroinflammation (TNF-, IL-1), MMP-9/2mediated extracellular matrix degradation, and HPA axis dysregulation

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Sci Rep 11(1):14612