Importantly, LBM remained largely stable, with slight gains in leg and arm FFM in some patients, resulting in minimal changes in skeletal muscle index and no cases of sarcopenia
These are often most prominent when starting the medication and may lessen over time
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The administration of DPP-4 promotes IR (115, 116), and insulin sensitivity has been shown to be improved when DPP-4 was down-regulated (111, 117)