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Resveratrol stimulates SIRT1, upregulating PPAR- and its downstream fatty acid oxidation genes, thereby enhancing hepatic lipogenesis and elevating circulating IGF-1 levels ( Generally, resveratrol suppresses adipogenesis through inhibition of C/EBP, downregulates C/EBP and PPAR- expressionkey drivers of fibroblast-to-adipocyte morphological transitionand enhances IGF-1 signaling pathway activation
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Wilson SH, Simari RD, Best PJ, Peterson TE, Lerman LO, Aviram M, Nath KA, Holmes DR, Lerman A: Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering
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