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GLP-1 receptor agonists like semaglutide trigger sustained appetite reduction and metabolic changes that produce average weight losses of 15 to 22 percent in clinical trials, significantly reducing joint compression and inflammatory stress

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The RT + PRO group showed significant gains in appendicular skeletal muscle mass index (ASMI) and handgrip strength (HGS), and these improvements remained higher than RT alone after de-training, indicating better long-term retention

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[Abstract]2021 Dec;43(12):e12893