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Components such as complex I and complex III of the ETC are recognized as significant sites for the production of ROS

Key handling errors that can cause problems include: Shaking the vial vigorously during reconstitution, which denatures the peptide Using sterile water instead of bacteriostatic water, which lacks preservatives and allows bacterial growth Storing reconstituted peptide at room temperature instead of refrigerated Leaving the vial exposed to light, which degrades photosensitive amino acids Using reconstituted peptide beyond its stability window, typically 3-4 weeks Properly handled AOD 9604 should be clear and colorless in solution

In cases where hypersensitivity is confirmed, desensitization protocols have been developed to allow patients to continue receiving necessary vitamin B12 supplementation safely

Document history Updated in August 2025 by Lisa Dal Pozzo (Mechanism of Action and Safety) and the CAM Cancer Collaboration

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