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The researchers compared the one-year risk of HF hospitalization or death in new users of each GLP-1 drug to the risk of those outcomes in a placebo group of patients taking sitagliptin, a diabetes drug known to have no impact on HFpEF

XLu: Conceptualization, Funding acquisition, Supervision, Writingreview and editing

doi:10.2337/diacare.27.8.1915

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[PMC free article: PMC6559987] [PubMed: 31186450] 277

Three isoforms operate in complementary compartments: SOD1 (Cu/Zn-SOD) in the cytosol/intermembrane space, SOD2 (Mn-SOD) in the mitochondrial matrix, and SOD3 extracellularly [99102]