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December 2023

These include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea (very common) Vomiting (common, affecting up to 1 in 10 people) Constipation (common) Abdominal pain (common) Reduced appetite (very common) These gastrointestinal effects typically occur during dose escalation and often diminish over time as the body adjusts to the medication

At this stage, arrestins are likely to be loosely associated with the receptor because the receptors are not yet activated and the intracellular crevices of activated receptors are not open

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not all results will happen immediately

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