Key weight loss results at 48 weeks by group: Response rates at 48 weeks (12 mg dose): 100% achieved greater than or equal to 5% weight loss 93% achieved greater than or equal to 10% weight loss 83% achieved greater than or equal to 15% weight loss The cardiometabolic improvements were also significant, with reductions in blood pressure, triglycerides, LDL cholesterol, HbA1c, fasting glucose, and fasting insulin across all dose groups
Saliva does far more than keep your mouth wet
doi: 10.1056/NEJMoa2407379 21 AronneLJHornDBle RouxCWHoWFalconBLValderasEGet al
They aren't FDA-approved, but they must come from a 503(A) compounding pharmacy, which follow strict FDA guidelines
GIP and GLP-1 effects on gastric emptying The secretion of endogenous GIP does not correlate with gastric half-emptying times (150)
Pharmacokinetically, these drugs are built for once-weekly dosing with long half-lives, so lower weekly doses really do produce lower overall exposure