The frequency of adverse effects was increased in the combination group and included headache, anorexia, constipation, epistaxis, and hypertension (Vahdat et al., 2017)
Therefore, improved mitochondrial function can lead to better cardiac efficiency and reduced symptoms of heart failure (Sciandra et al
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MOTS-c increases cellular NAD+ levels as part of its mechanism, so the two compounds work through complementary pathways rather than redundant ones
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