doi: 10.1155/2018/7462839.7462839 [DOI] [PMC free article] [PubMed] [Google Scholar] 12.Horn T
Full disclosure: Im a former employee of the American Chemical Society, which publishes Journal of Medicinal Chemistry, and a current contract writer for the societys Reactions video series.
doi:10.1177/20514158221132102
No, they are intrinsically linked
These medications are vastly different, despite being in the same medication class, agrees Jodie Pepin, Pharm.D., clinical pharmacy program manager at Harbor Health in Round Rock, Texas
The action of paracetamol at a molecular level is unclear but could be related to the production of reactive metabolites by the peroxidase function of COX-2, which could deplete glutathione, a cofactor of enzymes such as PGE synthase.