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Potential side effects include rash, swelling of the face and tongue (very rare), nausea, diarrhea, and headache
Indeed, generating a fusion or conjugation between a peptide and a carrier molecule such as an antibody Fc fragment 23,24 or a full antibody 25,26 is a well described half-life extension strategy to address their rapid clearance from circulation and improve their therapeutic potential
The company noted the candidate's competitive safety profile and sustained efficacy over 28 weeks, with plans to advance it into Phase 3 trials in 2026
Tesofensine works by inhibiting the reuptake of dopamine, norepinephrine, and serotonin, leading to appetite suppression and increased satiety
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