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One possible explanation for the similar effects on weight loss observed with both GIPR agonism and antagonism might be that chronic pharmacological GIPR activation induces functional antagonism in a subset of neurons through receptor desensitization, as seen in adipocytes, isolated pancreatic islets and mouse neuroblastoma Neuro2a cells 36,37

Errors here cascade through your entire protocol, causing incorrect concentrations, degraded peptides, and unreliable results

Suspected side effects may also be reported directly via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk) or the Yellow Card app

Lee DY, Kim EH

Res 124 , 216222 (2010)

de Wit HM, Vervoort GM, Jansen HJ, de Galan BE, Tack CJ