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Research suggests that the potential mechanism behind B12s ability to alleviate pain is through increasing nerve regeneration and decreasing ectopic nerve firing (which causes neuropathic pain)

The CARS level correlates positively with PD-L1 expression and may induce the trans-sulfur pathway, leading to cysteine deprivation and ferroptosis inhibition (103)

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Crystals trigger inflammasome activation 4,7,8,9 mainly through frustrated phagocytosis, a process characterized either by aberrant actin polymerization 10 or by lysosomal damage 11 , in which lysosome contents leak into the cytosol