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Androgens signal by binding to the androgen receptor (AR), which interacts with androgen response elements (AREs) and recruits co-activators and co-repressors to regulate transcription of AR target genes

Darvas M, Mukherjee K, Lee A, & Ladiges W

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Elevated blood glucose triggers hyperglucotoxicity, leading to aggravation of IR and deterioration of cell function, creating a vicious cycle that leads to further elevation of blood glucose to diabetic levels and even hyperglycemic crises