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Crucially, it was discovered that these systemic effects were linked to elevated expression of BCAA catabolic genes in mice's thermogenic BAT

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To perform labeling, cell culture medium was replaced with medium containing 500 M of probe and incubated at 37 C

That said, any new or worsening gastrointestinal symptomsparticularly persistent diarrhoea, rectal bleeding, severe abdominal pain, or unexplained weight loss beyond expected therapeutic effect should prompt medical evaluation

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NFIB is a governor of epithelialmelanocyte stem cell behaviour in a shared niche