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The hallmark features include persistent redness (erythema), flushing episodes triggered by heat, sun, alcohol, and spicy foods, visible small blood vessels (telangiectasias), and in some subtypes, papules and pustules that resemble acne

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Furthermore, activation of memory CD8 + T cells through CD8 antibody-mediated stimulation triggers downstream signaling of the T cell receptor, enhancing T cell-mediated cytotoxicity and promoting the production of effector cytokines, which is dependent on glucose and glutamine [133]