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Moreover, some benefits on clinical and metabolic features of PCOS may not have fully emerged due to the low or medium doses employed in the vast majority of the current studies

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Additionally, experts say those with more severe gastrointestinal diseases, such as gastroparesis and inflammatory bowel disease (IBD), should avoid these medications

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For diabetes, NICE recommends continuing treatment if HbA1c reduces by at least 11 mmol/mol (1.0%) and weight decreases by at least 3% at 6 months