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The functions of this HO-1 enzyme are regulatory signaling, immunomodulatory, and cytoprotective [157], and the HO-1 gene has a consensus sequence in the ARE domain

The results showed that exendin 939 restored nitrite, PGE 2 , and IL-6 secretion in liraglutide pretreated chondrocytes and macrophages in a dose-dependent manner ( p = 0.0022 compared with IL-1 + liraglutide group and p = 0.026 or p = 0.0022 compared with LPS + liraglutide group)