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Nature (2019) 569:42832

Avoid applying cold directly to injection sites within 30 minutes of injection

4.2 Consequence of the predicted mode of action of the thiol switch in GSAAT1 Structural insights into GSAAT that led us to speculate about the mechanism of action of the thiol switch prompts other questions, which we would like to discuss

This is harmful as it can lead to serious problems, such as dehydration and salt (electrolyte) disturbances, and in some cases dependence

PMCID: PMC4812798

While a few smaller peptides or those with special modifications might have slightly better oral bioavailability, injectable administration remains the gold standard for most peptide research to ensure efficacy.