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The safety profile of AOD-9604 is favorable compared to many metabolic interventions, with clinical trials involving approximately 900 participants demonstrating good tolerability and minimal side effects

In research settings, potential risks discussed for senolytic approaches include off-target cell stress, unintended effects on non-senescent cells, immune or inflammatory reactions, and organ-specific toxicity depending on exposure and route

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Compounds ranked 29 at 10 M did not exhibit adjuvant activity, suggesting that they did not sufficiently enhance metabolic activity to enable sensitization (Supplementary Fig

Cheng, F., Wang, Q., Chen, M., Quiocho, F

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