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ROS-induced impairment of the IFN response occurs in murine herpes virus infection, with the inhibition taking place downstream of cytoplasmic DNA sensing 59

The honest summary is that long-term human safety data is missing and the angiogenesis mechanism is an unresolved theoretical concern

Some clinical trials have used a total daily dose of 420 to 480 mg silymarin, divided into two or three doses daily

Kaufman HS, Magnuson TH, Pitt HA, Frasca P, Lillemoe KD