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Finally, rapamycin treatment increased the expression of Treg cell-associated cytokines, including IL-10 and TGF- in the small intestine of CMA mice (82)

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327 However, in T-cell, the NAD + depletion by elevated CD38 expression increases the acetylation of EZH2 by in a SIRT1-dependent manner, leading to reduced cytotoxicity of CD8 T cell and enhanced inclination to infections in patients with systemic lupus erythematosus (SLE)

doi:10.2174/0929867043455602

Farrell TW, Korniyenko A, Hu G, Fulmer T