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Ethics statement The animal study was reviewed and approved by the Animal Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology (HUST)

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Acknowledgements These studies were supported by grants from the Swedish Research Council (4792), the Free Masons in Stockholm for Children's Welfare, the Memory Foundation of Golje, the HRH Crown Princess Lovisa Foundation, the ke Wiberg Foundation, the Ronald McDonald Foundation, the Linna and Josef Carlsson Foundation, the Lennanders Foundation, the Swedish Society of Medicine, and the Samariten Foundation, which are gratefully acknowledged

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