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Tirzepatide, in contrast, may address the root cause: metabolic dysfunction

Lower-cost access during the boom helped thousands manage weight and related conditions, but the reckoning highlighted risks around quality consistency, supply stability, and treatment continuity

The STEP 8 clinical trials found that once-weekly semaglutide 2.4 mg led to significantly greater weight loss than once-daily liraglutide 3.0 mg at 68 weeks in overweight adults without diabetes

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This contributes to better metabolic balance

Resources Bttger, Franziska, et al