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Moreover, the optimization of siRNA chemical structures through modifications Such as 2-O-methylation, phosphorothioate linkages, and locked nucleic acids (LNAs) can significantly improve their stability, reduce immunogenicity, and fine-tune their silencing potency

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People with malabsorption, post-bariatric anatomy, or active inflammatory bowel disease can absorb nutrients through a vein that they cant absorb through their gut

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