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1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells

Phase 2a trial of GSBR-1290 (45mg and 90mg) in 54 T2DM patients over 12 weeks observed significant reduction in HbA1c (45 mg: -1.01%, p=0.008

The drug is an N-protected dipeptide and can be written as Pyz-Phe-boroLeu, which stands for pyrazinoic acid, phenylalanine, and leucine with a boronic acid instead of a carboxylic acid

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It would be interesting to see if signal integration at the level of the NTS was influenced by long term metabolic manipulations, and how that signal integration altered central GLP-1 signaling

These programs can reduce brand-name costs to $0 to $500/month, though eligibility restrictions apply and coverage can change with little notice